NIH: Genomics of HIV/AIDS Drug Response and Co-Morbidities, Deadline: 7 May 2020

The National Institutes of Health (NIH) is currently seeking proposals for its programme titled- Genomics ofHIV/AIDS Drug Response and Co-Morbidities.

The purpose of this funding opportunity announcement is to expand the use of high-throughput genotyping, genomic sequencing, and related genomic technologies, and generate resulting data resources widely available for research use, to improve the efficacy and safety and ease of use of HIV/AIDS therapies and of non-HIV drugs used to treat HIV/AIDS patients, and to reduce HIV/AIDS-related comorbidities, coinfections, and complications.

Research Topics

The research areas may include (not limited to) the following:

• Identifying genomic correlates of drug efficacy, toxicity and co-morbidity using dense SNP genotyping and/or targeted or whole exome/genome sequencing data in HIV/AIDS patients, and, as appropriate, a limited number of control patients not available through accessible databases;
• Developing, refining, and/or validating standardized drug efficacy, toxicity and co-morbidity phenotypes in well-characterized HIV/AIDS patients;
• Characterizing validated drug efficacy, toxicity and co-morbidity phenotypes in existing HIV/AIDS cohorts and clinical trial populations and relating them to available dense SNP genotyping or genomic sequencing data;
• Preparing genomic and phenotyping data for analysis and deposition for research access, by imputing genotyping data against appropriate reference populations, assigning phenotypes, correlating genetic variants with phenotypes, and other analytic processes as appropriate;
• Developing protocols for prospective collection of efficacy, toxicity and co-morbidity data in ancestrally diverse or minimally characterized cohorts available nationally and internationally.

Eligibility Criteria

• For profit organizations other than small businesses
• Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
• Others (see text field entitled “Additional Information on Eligibility” for clarification)
• Special district governments
• Public and State controlled institutions of higher education
• Public housing authorities/Indian housing authorities
• Native American tribal governments (Federally recognized)
• Private institutions of higher education
• State governments
• County governments
• Native American tribal organizations (other than Federally recognized tribal governments)
• Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
• Independent school districts
• Small businesses
• City or township governments
• Alaska Native and Native Hawaiian Serving Institutions
• Asian American Native American Pacific Islander Serving Institutions (AANAPISISs)
• Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations
• Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs)
• Indian/Native American Tribal Governments (Other than Federally Recognized)
• Non-domestic (non-U.S.) Entities (Foreign Organizations)
• Regional Organizations
• Tribally Controlled Colleges and Universities (TCCUs)
• U.S. Territory or Possession
• Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
• Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.
• Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

How to Apply

Applications must be submitted online via given website.

For more information, please visit Grants.gov.